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    The effects of Candida albicans isolated from human feces and standard Lactobacillus plantarum on colorectal cancer

  • Kimiya Shams,1 Mohaddeseh Larypoor,2,* Jafar Salimian,3
    1. Faculty of Biological Science, Department o Biotechnology, Islamic Azad University, North Tehran Branch, Iran
    2. Faculty of Biological Science, Department of Microbiology, Islamic Azad University, North Tehran Branch, Iran
    3. Faculty of Biological Science, Department of Microbiology, Baqiatallah University


  • Introduction: In recent studies, Probiotics have been shown to mediate anti-cancer effects through the immune system. The aim of this study was to investigate the effects of Lactobacillus plantarum and Candida albicans on the process of colorectal cancer caused by fatty foods and azoxymethane in rats.
  • Methods: Male Fisher 344 rats were divided into 6 groups of 5. One group received fatty foods with liquid oil and the other group received fatty foods and azoxymethane. The third group received only azoxymethane and after proving cancer, the groups were treated separately with Lactobacillus plantarum standard, Candida albicans isolated from the elderly's gastrointestinal tract, and a chemotherapy drug. Candida albicans isolated from human feces were evaluated by biochemical, microbiological, and PCR methods. After treatment of the groups, the serum levels of IFN-γ, IL-4 and TGF-β, and TNF-α were measured by ELISA, and the intestinal tissues of rats were examined pathologically.
  • Results: The results showed that cancer cells in groups treated with chemotherapy and microorganisms developed apoptosis, which was characterized by shrinkage and darkening of cell nuclei. Serum levels of IFN-γ, IL-4, and TGF-β significantly decreased compared to the control group (P<0.05).
  • Conclusion: Microorganisms of the microbial flora of the gastrointestinal tract of the elderly and healthy people play an effective role in improving gastrointestinal diseases because their probiotic properties are effective in controlling and preventing diseases.
  • Keywords: Colorectal cancer, IFN-γ, IL-4, TGF-β, TNF-α