Nanobiotechnology and application of the surface layer of bacteria for the preparation of anti-cancer vaccines
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Yegane Zahiri,1,* Roghayeh Gholizadeh Doran Mahalleh,2
1. Medical student, member of Young and Elite Researchers Club of Islamic Azad University, Zahedan, Iran
2. Department of laboratory sciences, Zahedan branch, Islamic Azad university, Zahedan, Iran
- Introduction: When cancer cell antigens are injected into the body, it does not elicit an immune response, but if combined with the surface layer, it induces a T cell response, NK cells and macrophages and the removal of cancer cells. Simon and colleagues chemically attached carcinogenic glycans such as T-glycans and Lewisy antigen to the surface layer, which retains its cumulative properties and induces strong immune responses. The goal is to use the surface layer of bacteria to make a cancer vaccine.
- Methods: In this study, a review of new articles in scientific databases was searched and finally used to organize the article.
- Results: Most of the surface layer of bacteria such as Bacillus stearothermophilus Clostridium; Thermohydrosulfuricum and Bacillus aloe. Lactobacillus brevis is one of the most important candidates for anti-cancer vaccine, which is of special importance due to its probiotic properties and ability to grow at acidic pH and resistance to biliary bile salts. It is used as a C_myk adjuvant, which is a proto-oncogene. The surface layer of this bacterium is also used to treat viral infections.
- Conclusion: The surface layer has potential applications for making epitope carriers for use in certain vaccines, especially the bacterium Caulobacter crescentus is a bacterium of the environment and nature and is not pathogenic and the protein expression system is very stable and the surface layer protein secretion is high and it can be used for mass production of recombinant protein.
- Keywords: Nanobiotechnology; Applied; Surface layer; bacteria ; vaccine ; Anticancer
