effective factor to change spermatogenesis in multiple sclerosis
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armin sharifi,1,* mehran radak,2 hosein mohammadi,3 shahab atefi,4
1. medical science of kermanshah
- Introduction: behavioral and cognitive disabilities are rooted in Neurodegenerative diseases are rooted in the central nervous system (CNS). abnormalities in the genome and/or metabolism in brains stems Neurodegenerative diseases such as Multiple sclerosis (MS) is a chronic disability disease which is one of common disease in the world.in this study we investigate the cause of death ratio in PPMS patient.
- Methods: In order to start this study, we used GEO accession number GSE131282. In our work, we considered patients with disease duration 54 PPMS years in PPMS as control groups and disease duration 4 years as treatment groups and by the use the limma package in R software data was analyzed. differentially expressed genes (DEGs) list by utilizing string database was analyzed to build Protein-protein interaction (PPI) network. Cytoscape 3.4.0 have been software that construct modules and Gephi software visualized our network.
- Results: In case of PPMS, the number of DEGs were 845 genes which 707 were upregulated and 138 were downregulated. analysis of modules shows that translation and regulation of apoptotic process are two major function. in addition, top ten of nodes determine as hubs genes such as RPL11and PLEC.
- Conclusion: Our study illustrated that changing in expression of TP53 and MAPK14 and so on can affected violence of PPMS disease. Thus patient with type of intensive PPMS has drastically decrease in spermatogenesis and cell differentiation.
- Keywords: #multiple_sclerosis#MAPK14 #TP53
