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    Bioinformatics study of the correlation between gene expression, race and survival in patients with LUSC( lung squamous cell carcinoma)

  • Zahra Firoozi,1,*
    1. Tarbiat Modares University


  • Introduction: Studies have shown that the incidence of LUSC ) lung squamous cell carcinoma( is related to various environmental factors, including race. However, the related molecular mechanisms have received less attention. In this study, the identification of genes whose expression changes are related to cancer and patients' race, as well as the relationship between the expression of these genes and survival rate.
  • Methods: TCGA data were used to identify the expression of altered genes in LUSC) lung squamous cell carcinoma( and the relationship between gene expression and patients' race. For this purpose, OncoDB database was used and gene expression was normalized by TMP method. To compare the groups, cancer samples were first evaluated compared to normal. The similarity between genes with different expression in cancer and genes affecting patients' races was also examined. Finally, the correlation between the desired genes and patient survival was investigated.
  • Results: The results of expression differences between cancer samples compared to normal showed that 1000 genes were significantly (p> 0.01) and expressed with lLogFCl> 2 expression criteria. On the other hand, the results of the study of the relationship between gene expression and patients 'race showed that the expression of 216 genes was related to patients' race (p <0.0001). Among the genes identified in the previous stages, the results showed that there were 7 genes that had both increased expression and were related to the patients' race. Among these 7 genes, only changes in PLAAT1 expression were correlated with decreased survival rate.
  • Conclusion: Our results show that the PLAAT1 was overexpressed in cancer samples and was related to patients' race. On the other hand, increasing and decreasing the expression of this gene leads to a decrease in survival rate. Therefore, the results of PLAAT1 can be a good treatment candidate for LUSC )lung squamous cell carcinoma( patients of African American descent.
  • Keywords: LUSC, race, survival